People who consume a cholesterol-lowering drugs (especially class of drugs called statins) in high doses has the possibility to develop kidney problems, a new study suggests.
Specifically, the study participants were taking statins in high doses is known as much as 34 percent of hospitalized due to acute kidney damage during the 120 days of treatment compared to the other participants who consumed only in low doses. This risk is still increased, although it has been two years after treatment begins. These results were published online in the journal BMJ, 19 March.
Statins are commonly prescribed to lower cholesterol levels in the blood and can work effectively. However, these drugs still have a risk to the health of the body, especially the liver damage and muscle pain. As for the effects on the kidneys as discussed in this study, is relatively new.
Researchers from Canada analyzed the health of more than 2 million people aged 40 years and above all with or without kidney disease who took statins. High doses of statins, including rosuvastatin (Crestor) at a dose of 10 mg or more, atorvastatin (Lipitor) at a dose of 20 mg or more, and simvastatin (Zocor) at a dose of 40 mg. All doses of other statins are considered a low dose.
The findings of the study showed that people with kidney disease do not have a high risk of experiencing acute kidney problems on consumption of statins.
The researchers say that if statins can cause liver damage or not, it is still not known with certainty. But there is a strong link between consumption of statins in high doses with increased risk of muscle damage. Additionally, statins have been shown to block the production of coenzyme Q10 (a substance in the body that help break down food), which theoretically can cause health problems in the kidneys.
Colin Dormuth, an author of the study says that other studies also have shown an association between statin therapy with protein in the urine, where it is a hallmark of kidney disease.
Signs of kidney problems a person can be seen from a dark-colored urine, difficulty urinating. Experts suggest if you feel statins in high doses and then experience problems with urination, you should immediately contact a doctor.
However, other experts said the study did not show a causal relationship between high doses of statins with acute kidney damage.
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